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T1  - Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children 
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UR  - http://hdl.handle.net/10138/321125 
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A1  - Tenhu, Elina; Teräsjärvi, Johanna; Cruzeiro, Manuel Leite; Savonius, Okko; Rugemalira, Emilie; Roine, Irmeli; He, Qiushui; Pelkonen, Tuula 
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Y1  - 2020 
LA  - eng 
AB  - Bacterial meningitis (BM) is a severe disease caused by various bacterial pathogens. Toll-like receptors (TLRs) protect humans from invading pathogens. In this study, we determined whether single nucleotide polymorphisms (SNPs) ofTLR4andTLR9are associated with susceptibility to and outcome of BM in Angolan children. Samples were taken from 241 patients and 265 age-matched ethnic controls. The SNPsTLR4rs4986790 (896A > G) andTLR9rs187084 (-1486T > C) were determined by high-resolution melting ana... 
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KW  - TLR4; TLR9; gene polymorphisms; meningitis; Haemophilus influenzae; HRMA; children; Angola; TOLL-LIKE RECEPTOR-4; SINGLE NUCLEOTIDE POLYMORPHISMS; CHILDHOOD BACTERIAL-MENINGITIS; HAEMOPHILUS-INFLUENZAE; STREPTOCOCCUS-PNEUMONIAE; CEREBROSPINAL-FLUID; SUSCEPTIBILITY; TOLL-LIKE-RECEPTOR-4; MUTATIONS; 3111 Biomedicine; 1184 Genetics, developmental biology, physiology 
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