TY - T1 - Genetic Control of Myelin Plasticity after Chronic Psychosocial Stress SN - / UR - http://hdl.handle.net/10138/293045 T3 - A1 - Laine, Mikaela A.; Trontti, Kalevi; Misiewicz, Zuzanna; Sokolowska, Ewa; Kulesskaya, Natalia; Heikkinen, Aino; Saarnio, Suvi; Balcells, Ingrid; Ameslon, Pierre; Greco, Dario; Mattila, Pirkko; Ellonen, Pekka; Paulin, Lars; Auvinen, Petri; Jokitalo, Eija; Hovatta, Iiris A2 - PB - Y1 - 2018 LA - eng AB - Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress, but the mechanisms underlying these gene-environment interactions are largely unknown. We used the chronic social defeat stress (CSDS) mouse model to study resilience and susceptibility to chronic psychosocial stress. We identified a strong genetic background effect in CSDS-induced social avoidance (SA) using four inbred mouse strains: 69% of C57BL/6NCrl (B6), 23% of BALB/cAnNCrl, 19% of 129S2/SvPa... VO - IS - SP - OP - KW - anxiety; chronic social defeat stress; inbred mouse strain; myelin; RNA-sequencing; transmission electron microscopy; SOCIAL DEFEAT STRESS; CENTRAL-NERVOUS-SYSTEM; RECEPTOR-LIKE IMMUNOREACTIVITY; MEDIAL PREFRONTAL CORTEX; ANXIETY DISORDERS; EXPRESSION DATA; MOUSE STRAINS; MILD STRESS; BALB/C MICE; DEPRESSION; 318 Medical biotechnology N1 - PP - ER -