TY  -  
T1  - Genetic determinants of circulating GIP and GLP-1 concentrations 
SN  -  /  
UR  - http://hdl.handle.net/10138/299215 
T3  -  
A1  - Almgren, Peter; Lindqvist, Andreas; Krus, Ulrika; Hakaste, Liisa; Ottosson-Laakso, Emilia; Asplund, Olof; Sonestedt, Emily; Prasad, Rashmi B.; Laurila, Esa; Orho-Melander, Marju; Melander, Olle; Tuomi, Tiinamaija; Holst, Jens Juul; Nilsson, Peter M.; Wierup, Nils; Groop, Leif; Ahlqvist, Emma 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - The secretion of insulin and glucagon from the pancreas and the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) from the gastrointestinal tract is essential for glucose homeostasis. Several novel treatment strategies for type 2 diabetes (T2D) mimic GLP-1 actions or inhibit incretin degradation (DPP4 inhibitors), but none is thus far aimed at increasing the secretion of endogenous incretins. In order to identify new potential therapeutic target... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - GENOME-WIDE ASSOCIATION; GLUCAGON-LIKE PEPTIDE-1; BODY-MASS INDEX; INSULIN-RESISTANCE; MALMO DIET; CHOLESTEROL ABSORPTION; MOLECULAR-MECHANISMS; GLUCOSE-ABSORPTION; FASTING GLUCOSE; LOCI; 3111 Biomedicine 
N1  -   
PP  -  
ER  -