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T1  - Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error 
SN  -  /  
UR  - http://hdl.handle.net/10138/314237 
T3  -  
A1  - Consortium Refractive Error Myopia; UK Biobank Eye Vision Consortium; Fan, Qiao; Pozarickij, Alfred; Tan, Nicholas Y. Q.; Wedenoja, Juho; Pärssinen, Olavi; Hammond, Christopher J. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in 44,042 individuals of Caucasian and Asian with replication in 88,218 UK Biobank data. We identified 47 loci (of which 26 are novel), with population-specific signals as well as shared signals across ethnicities. Some identified variants showed precise scaling in corneal cu... 
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KW  - OCULAR COMPONENT DIMENSIONS; SPHERICAL EQUIVALENT; EXPRESSION PATTERNS; EYE SIZE; VARIANTS; MULTIPLE; HERITABILITY; KERATOCONUS; POPULATION; COLLAGEN; 3111 Biomedicine; 3125 Otorhinolaryngology, ophthalmology 
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ER  -