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T1  - Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation 
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UR  - http://hdl.handle.net/10138/183448 
T3  -  
A1  - Lorey, Martina B.; Rossi, Katriina; Eklund, Kari; Nyman, Tuula A.; Matikainen, Sampsa 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Gram-negative bacteria are associated with a wide spectrum of infectious diseases in humans. Inflammasomes are cytosolic protein complexes that are assembled when the cell encounters pathogens or other harmful agents. The non-canonical caspase-4/5 inflammasome is activated by Gram-negative bacteria-derived lipopolysaccharide (LPS) and by endogenous oxidized phospholipids. Protein secretion is a critical component of the innate immune response. Here, we have used label-free quantitative proteomic... 
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KW  - DENDRITIC CELLS; PROTEOMICS; LPS; INFECTION; IMMUNITY; EXOSOMES; SHOCK; TRANSLATION; PROTEASES; PATHWAYS; 1182 Biochemistry, cell and molecular biology; 3111 Biomedicine 
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