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T1  - HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD 
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UR  - http://hdl.handle.net/10138/315191 
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A1  - Laitakari, Anna; Tapio, Joona; Mäkelä, Kari A.; Herzig, Karl-Heinz; Dengler, Franziska; Gylling, Helena; Walkinshaw, Gail; Myllyharju, Johanna; Dimova, Elitsa Y.; Serpi, Raisa; Koivunen, Peppi 
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Y1  - 2020 
LA  - eng 
AB  - Non-alcoholic fatty liver disease (NAFLD) parallels the global obesity epidemic with unmet therapeutic needs. We investigated whether inhibition of hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2), a key cellular oxygen sensor whose inhibition stabilizes HIF, would protect from NAFLD by subjecting HIF-P4H-2-deficient (Hif-p4h-2(gt/gt)) mice to a high-fat, high-fructose (HFHF) or high-fat, methionine-choline-deficient (HF-MCD) diet. On both diets, the Hif-p4h-2(gt/gt) mice gained less ... 
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KW  - Fructose; HIF; Hypoxia response; Metabolism; NAFLD; CHOLINE-DEFICIENT MODEL; FATTY LIVER-DISEASE; ADIPOSE-TISSUE; INSULIN-RESISTANCE; LIPID-METABOLISM; MOUSE MODEL; HYPOXIA; GLUCOSE; OBESITY; MICE; 1184 Genetics, developmental biology, physiology; 3121 General medicine, internal medicine and other clinical medicine 
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