TY - T1 - HUS and atypical HUS SN - / UR - http://hdl.handle.net/10138/190710 T3 - A1 - Jokiranta, T. Sakari A2 - PB - Y1 - 2017 LA - eng AB - Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by intravascular hemolysis, thrombocytopenia, and acute kidney failure. HUS is usually categorized as typical, caused by Shiga toxin-producing Escherichia coli (STEC) infection, as atypical HUS (aHUS), usually caused by uncontrolled complement activation, or as secondary HUS with a coexisting disease. In recent years, a general understanding of the pathogenetic mechanisms driving HUS has increased. Typical HUS (ie, STE... VO - IS - SP - OP - KW - HEMOLYTIC-UREMIC SYNDROME; THROMBOTIC THROMBOCYTOPENIC PURPURA; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; ALTERNATIVE COMPLEMENT PATHWAY; CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TISSUE FACTOR ACTIVITY; FACTOR-H; SHIGA-TOXIN; ENDOTHELIAL-CELLS; 3122 Cancers; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -