TY  -  
T1  - HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage 
SN  -  /  
UR  - http://hdl.handle.net/10138/308993 
T3  -  
A1  - Loppi, S.; Kolosowska, N.; Kärkkäinen, O.; Korhonen, P.; Huuskonen, M.; Grubman, A.; Dhungana, H.; Wojciechowski, S.; Pomeshchik, Y.; Giordano, M.; Kagechika, H.; White, A.; Auriola, S.; Koistinaho, J.; Landreth, G.; Hanhineva, K.; Kanninen, K.; Malm, T. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Ischemic stroke is amongst the leading causes of death and disabilities. The available treatments are suitable for only a fraction of patients and thus novel therapies are urgently needed. Blockage of one of the cerebral arteries leads to massive and persisting inflammatory reaction contributing to the nearby neuronal damage. Targeting the detrimental pathways of neuroinflammation has been suggested to be beneficial in conditions of ischemic stroke. Nuclear receptor 4A-family (NR4A) member Nurr1... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Stroke; Neuroinflammation; Microglia; Nuclear receptors; Metabolic profiling; MIDDLE CEREBRAL-ARTERY; FACTOR-KAPPA-B; ORPHAN NUCLEAR RECEPTORS; NITRIC-OXIDE SYNTHASE; IMMEDIATE-EARLY GENES; MOUSE STROKE MODEL; RESONANCE-SPECTROSCOPY; MOLECULAR-MECHANISMS; PHOSPHOLIPASE A(2); OXIDATIVE STRESS; 3112 Neurosciences 
N1  -   
PP  -  
ER  -