TY  -  
T1  - Habitual coffee consumption and cognitive function : a Mendelian randomization meta-analysis in up to 415,530 participants 
SN  -  /  
UR  - http://hdl.handle.net/10138/235449 
T3  -  
A1  - Zhou, Ang; Taylor, Amy E.; Karhunen, Ville; Zhan, Yiqiang; Rovio, Suvi P.; Lahti, Jari; Sjögren, Per; Byberg, Liisa; Lyall, Donald M.; Auvinen, Juha; Lehtimaki, Terho; Kahonen, Mika; Hutri-Kahonen, Nina; Perala, Mia Maria; Michaelsson, Karl; Mahajan, Anubha; Lind, Lars; Power, Chris; Eriksson, Johan G.; Raitakari, Olli T.; Hagg, Sara; Pedersen, Nancy L.; Veijola, Juha; Jarvelin, Marjo-Riitta; Munafo, Marcus R.; Ingelsson, Erik; Llewellyn, David J.; Hypponen, Elina 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid-to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using ava... 
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OP  -  
KW  - DOSE-RESPONSE METAANALYSIS; GENOME-WIDE ASSOCIATION; CAFFEINE INTAKE; CARDIOVASCULAR-DISEASE; PROSPECTIVE COHORT; RISK; INSTRUMENTS; HYPERTENSION; IMPAIRMENT; NONSMOKERS; 515 Psychology; 3121 General medicine, internal medicine and other clinical medicine 
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ER  -