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T1  - Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure 
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UR  - http://hdl.handle.net/10138/305344 
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A1  - HOT-ICU Investigators; Schjorring, Olav L.; Perner, Anders; Wetterslev, Jorn; Lange, Theis; Keus, Frederik; Laake, Jon H.; Okkonen, Marjatta; Siegemund, Martin; Morgan, Matthew; Thormar, Katrin M.; Rasmussen, Bodil S. 
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Y1  - 2019 
LA  - eng 
AB  - Background Acutely ill adults with hypoxaemic respiratory failure are at risk of life-threatening hypoxia, and thus oxygen is often administered liberally. Excessive oxygen use may, however, increase the number of serious adverse events, including death. Establishing the optimal oxygenation level is important as existing evidence is of low quality. We hypothesise that targeting an arterial partial pressure of oxygen (PaO2) of 8 kPa is superior to targeting a PaO2 of 12 kPa in adult intensive car... 
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KW  - critical illness; hyperoxia; hypoxia; intensive care units; mortality; oxygen inhalation therapy; pragmatic clinical trial; randomised controlled trial; respiratory insufficiency; MECHANICALLY VENTILATED PATIENTS; CRITICALLY-ILL PATIENTS; ARTERIAL HYPEROXIA; PRACTICE GUIDELINE; CRITICAL ILLNESS; OUTCOMES; MORTALITY; THERAPY; SEPSIS; ATELECTASIS; 3126 Surgery, anesthesiology, intensive care, radiology 
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