TY  -  
T1  - Heikkojen emästen in vivo -liukenemisen, -saostumisen ja -uudelleenliukenemisen arvioiminen in vitro - dissoluutiomenetelmällä lääkekehityksen alkuvaiheessa 
SN  -  /  
UR  - URN:NBN:fi-fe201801151233; http://hdl.handle.net/10138/40770 
T3  -  
A1  - Kyynäräinen, Kerttu 
A2  -  
PB  - Helsingfors universitet 
Y1  - 2013 
LA  - fin 
AB  - In vivo dissolution of drug molecules depends on the conditions in the gastrointestinal tract, like pH, composition of the fluids and hydrodynamics. Weakly basic compounds dissolve rapidly in low pH in stomach but in intestinal conditions forming of supersaturated solution may occur. This unstable state is the driving force either for rapid absorption from small intestine or for possible precipitation of drug. Difference in precipitation and thus in bioavailability between fasted and fed states ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - heikko emäs; liukeneminen; in vivo -saostuminen; uudelleenliukeneminen; in vitro -dissoluutio; Industriell farmaci; Industrial pharmacy; Teollisuusfarmasia 
N1  -   
PP  -  
ER  -