TY  -  
T1  - Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix 
SN  -  /  
UR  - http://hdl.handle.net/10138/223899 
T3  -  
A1  - Kanninen, Liisa K.; Porola, Pauliina; Niklander, Johanna; Malinen, Melina M.; Corlu, Anne; Guguen-Guillouzo, Christiane; Urtti, Arto; Yliperttula, Marjo L.; Lou, Yan-Ru 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - Human hepatocytes are extensively needed in drug discovery and development. Stem cell-derived hepatocytes are expected to be an improved and continuous model of human liver to study drug candidates. Generation of endoderm-derived hepatocytes from human pluripotent stem cells (hPSCs), including human embryonic stem cells and induced pluripotent stem cells, is a complex, challenging process requiring specific signals from soluble factors and insoluble matrices at each developmental stage. In this ... 
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IS  -  
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KW  - Extracellular matrix; Acellular matrix; Human embryonic stem cell; Human induced pluripotent stem cell; Hepatic differentiation; HepaRG; HEPATOCYTE-LIKE CELLS; DEFINITIVE ENDODERM CELLS; EXTRACELLULAR-MATRIX; EFFICIENT DIFFERENTIATION; 3-DIMENSIONAL CULTURE; TRANSCRIPTION FACTORS; SODIUM-BUTYRATE; EXPRESSION; GROWTH; FETAL; 317 Pharmacy; 1182 Biochemistry, cell and molecular biology 
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ER  -