TY  -  
T1  - High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro 
SN  -  /  
UR  - http://hdl.handle.net/10138/321957 
T3  -  
A1  - Torrente, Laura; Maan, Gunjit; Rezig, Asma Oumkaltoum; Quinn, Jean; Jackson, Angus; Grilli, Andrea; Casares, Laura; Zhang, Ying; Kulesskiy, Evgeny; Saarela, Jani; Bicciato, Silvio; Edwards, Joanne; Dinkova-Kostova, Albena T.; de la Vega, Laureano 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Aberrant hyperactivation of nuclear factor erythroid 2 (NF-E2) p45-related factor 2 (NRF2) is a common event in many tumour types and associates with resistance to therapy and poor patient prognosis; however, its relevance in colorectal tumours is not well-established. Measuring the expression of surrogate genes for NRF2 activity in silico, in combination with validation in patients' samples, we show that the NRF2 pathway is upregulated in colorectal tumours and that high levels of nuclear NRF2 ... 
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KW  - NRF2; colorectal cancer; drug screening; SMALL-MOLECULE INHIBITOR; POTENT AURORA KINASE; PHASE-I; NEGATIVE REGULATION; LUNG-CARCINOMA; TUMOR-GROWTH; KEAP1; RESISTANCE; PATHWAY; EXPRESSION; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology 
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