TY  -  
T1  - High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils 
SN  -  /  
UR  - http://hdl.handle.net/10138/313336 
T3  -  
A1  - Aaltonen, Niina; Singha, Prosanta K; Jakupović, Hermina; Wirth, Thomas; Samaranayake, Haritha; Pasonen-Seppänen, Sanna; Rilla, Kirsi; Varjosalo, Markku; Edgington-Mitchell, Laura E; Kasperkiewicz, Paulina; Drag, Marcin; Kälvälä, Sara; Moisio, Eemeli; Savinainen, Juha R; Laitinen, Jarmo T 
A2  -  
PB  - BioMed Central 
Y1  - 2020 
LA  -  
AB  - Abstract
              
                Background
                Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using fluorophosphonate (FP) probes has been a powerful chemoproteomic approach in studies unveiling roles of SHs in various biological systems. ABPP utilizes cell/tissue proteomes and features the FP-... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Activity-based protein profiling (ABPP); Brain cryosection; Glioblastoma multiforme (GBM); Immunohistochemistry; Serine hydrolase activity; Neutrophil serine protease (NSP); TAMRA-FP probe; Tumor-associated neutrophils 
N1  -   
PP  -  
ER  -