TY  -  
T1  - High-throughput compound screening identifies navitoclax combined with irradiation as a candidate therapy for HPV-negative head and neck squamous cell carcinoma 
SN  -  /  
UR  - http://hdl.handle.net/10138/334783 
T3  -  
A1  - Tuomainen, Katja; Hyytiäinen, Aini; Al-Samadi, Ahmed; Ianevski, Philipp; Ianevski, Aleksandr; Potdar, Swapnil; Turunen, Laura; Saarela, Jani; Kuznetsov, Sergey; Wahbi, Wafa; Risteli, Maija; Mäkitie, Antti; Monni, Outi; Salo, Tuula 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Conventional chemotherapeutic agents are nonselective, often resulting in severe side effects and the development of resistance. Therefore, new molecular-targeted therapies are urgently needed to be integrated into existing treatment regimens. Here, we performed a high-throughput compound screen to identify a synergistic interaction between ionizing radiation and 396 anticancer compounds. The assay was run using five human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSC... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - CANCER; COMBINATION; 3122 Cancers 
N1  -   
PP  -  
ER  -