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T1  - Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children 
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UR  - http://hdl.handle.net/10138/338561 
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A1  - DIABIMMUNE Study Grp; Reinert-Hartwall, Linnea; Siljander, Heli; Härkönen, Taina; Vatanen, Tommi; Ilonen, Jorma; Niemelä, Onni; Luopajärvi, Kristiina; Dorshakova, Natalya; Mokurov, Sergei; Peet, Aleksandr; Tillmann, Vallo; Uibo, Raivo; Knip, Mikael; Vaarala, Outi; Honkanen, Jarno 
A2  -  
PB  -  
Y1  - 2022 
LA  - eng 
AB  - Background Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune-mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load. Methods We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the particip... 
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KW  - allergic sensitization; cytokine; epidermal growth factor; epithelial integrity; IgE; T helper cell; EPIDERMAL-GROWTH-FACTOR; TIGHT JUNCTIONAL ZO-1; FACTOR-ALPHA; ALLERGY PREVALENCE; ASTHMA; EXPRESSION; FINNISH; ATOPY; MICROBIOTA; RESPONSES; 3121 General medicine, internal medicine and other clinical medicine 
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