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T1  - Human ROBO1 regulates white matter structure in corpus callosum 
SN  -  /  
UR  - http://hdl.handle.net/10138/205960 
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A1  - Darki, Fahimeh; Massinen, Satu; Salmela, Elina; Matsson, Hans; Peyrard-Janvid, Myriam; Klingberg, Torkel; Kere, Juha 
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PB  -  
Y1  - 2017 
LA  - eng 
AB  - The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five polymorphisms in the regulatory region of ROBO1 were associated with white matter dens... 
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KW  - Structural MRI; DTI; Single nucleotide polymorphism; Roundabout; Axon guidance receptor homolog 1; Axonal pathfinding; CORTICAL INTERNEURONS; CEREBRAL-CORTEX; MIGRATION; FOREBRAIN; GENE; MICROSTRUCTURE; ASSOCIATION; GUIDANCE; TRACTS; SLIT; 3111 Biomedicine; 3112 Neurosciences; 3124 Neurology and psychiatry 
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