TY  -  
T1  - Human Tumor-Derived Matrix Improves the Predictability of Head and Neck Cancer Drug Testing 
SN  -  /  
UR  - http://hdl.handle.net/10138/314700 
T3  -  
A1  - Tuomainen, Katja; Al-Samadi, Ahmed; Potdar, Swapnil; Turunen, Laura; Turunen, Minna; Karhemo, Piia-Riitta; Bergman, Paula; Risteli, Maija; Åström, Pirjo; Tiikkaja, Riia; Grenman, Reidar; Wennerberg, Krister; Monni, Outi; Salo, Tuula 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - In vitro cancer drug testing carries a low predictive value. We developed the human leiomyoma-derived matrix "Myogel" to better mimic the human tumor microenvironment (TME). We hypothesized that Myogel could provide an appropriate microenvironment for cancer cells, thereby allowing more in vivo-relevant drug testing. We screened 19 anticancer compounds, targeting the epidermal growth factor receptor (EGFR), MEK, and PI3K/mTOR on 12 head and neck squamous cell carcinoma (HNSCC) cell lines culture... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - head and neck cancer; drug screening; human tumor microenvironment; clinical trials; in vitro 3D; SQUAMOUS-CELL CARCINOMA; PHASE-II TRIAL; RECURRENT; PATHWAY; INHIBITOR; CETUXIMAB; SYSTEMS; ZD1839; EGFR; 3122 Cancers 
N1  -   
PP  -  
ER  -