TY  -  
T1  - Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p 
SN  -  /  
UR  - http://hdl.handle.net/10138/335659 
T3  -  
A1  - Ahonen, Maria A.; Asghar, Muhammad Yasir; Parviainen, Suvi J.; Liebisch, Gerhard; Höring, Marcus; Leidenius, Marjut; Fischer-Posovszky, Pamela; Wabitsch, Martin; Mikkola, Tomi S.; Törnquist, Kid; Savolainen-Peltonen, Hanna; Haridas, P. A. Nidhina; Olkkonen, Vesa M. 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - MicroRNA-221-3p (miR-221-3p) is associated with both metabolic diseases and cancers. However, its role in terminal adipocyte differentiation and lipid metabolism are uncharacterized. miR-221-3p or its inhibitor was transfected into differentiating or mature human adipocytes. Triglyceride (TG) content and adipogenic gene expression were monitored, global lipidome analysis was carried out, and mechanisms underlying the effects of miR-221-3p were investigated. Finally, cross-talk between miR-221-3p... 
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IS  -  
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OP  -  
KW  - Adipose tissue; Breast cancer; Lipid storage; Lipogenesis; microRNA; Sphingolipid; HIGH-THROUGHPUT QUANTIFICATION; NECROSIS-FACTOR-ALPHA; HUMAN ADIPOSE-TISSUE; BREAST-CANCER; INSULIN-RESISTANCE; CELL-PROLIFERATION; ADIPONECTIN; EXPRESSION; MICRORNAS; OBESE; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology 
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ER  -