TY  -  
T1  - Human cell transformation by combined lineage conversion and oncogene expression 
SN  -  /  
UR  - http://hdl.handle.net/10138/334405 
T3  -  
A1  - Sahu, Biswajyoti; Pihlajamaa, Päivi; Zhang, Kaiyang; Palin, Kimmo; Ahonen, Saija; Cervera, Alejandra; Ristimäki, Ari; Aaltonen, Lauri A.; Hautaniemi, Sampsa; Taipale, Jussi 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Cancer is the most complex genetic disease known, with mutations implicated in more than 250 genes. However, it is still elusive which specific mutations found in human patients lead to tumorigenesis. Here we show that a combination of oncogenes that is characteristic of liver cancer (CTNNB1, TERT, MYC) induces senescence in human fibroblasts and primary hepatocytes. However, reprogramming fibroblasts to a liver progenitor fate, induced hepatocytes (iHeps), makes them sensitive to transformation... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - HEPATOCELLULAR-CARCINOMA; HUMAN FIBROBLASTS; RAS ONCOGENES; CANCER; TUMOR; GENES; MYC; METHYLATION; INDUCTION; TUMORIGENESIS; 3122 Cancers 
N1  -   
PP  -  
ER  -