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T1  - Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG 
SN  -  /  
UR  - http://hdl.handle.net/10138/274087 
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A1  - Koistinen, Hannu; Koel, Mariann; Peters, Maire; Rinken, Ago; Lundin, Karolina; Tuuri, Timo; Tapanainen, Juha S.; Alfthan, Henrik; Salumets, Andres; Stenman, Ulf-Håkan; Lavogina, Darja 
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PB  -  
Y1  - 2019 
LA  - eng 
AB  - While human chorionic gonadotropin (hCG) appears to have an essential role in early pregnancy, it is controversial whether the hyperglycosylated form of hCG (hCG-h), which is the major hCG isoform during the first 4-5 weeks of pregnancy, is able to activate LH/hCG receptor (LHCGR). To address this, we utilized different extensively characterized hCG and hCG beta reference reagents, cell culture- and urine-derived hCG-h preparations, and an in vitro reporter system for LHCGR activation. The WHO h... 
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KW  - hCG; Hyperglycosylated hCG; LHCGR; LH/hCG receptor; Reporter system; HUMAN CHORIONIC-GONADOTROPIN; FREE BETA-SUBUNIT; HUMAN CHORIOGONADOTROPIN; GLYCOPROTEIN HORMONES; LUTEINIZING-HORMONE; BIOLOGICAL-ACTIVITY; 1ST TRIMESTER; PREGNANCY; ISOFORMS; TROPHOBLAST; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology 
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