TY  -  
T1  - Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma 
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UR  - http://hdl.handle.net/10138/314536 
T3  -  
A1  - Miikkulainen, Petra; Högel, Heidi; Seyednasrollah, Fatemeh; Rantanen, Krista; Elo, Laura L.; Jaakkola, Panu M. 
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PB  -  
Y1  - 2019 
LA  - eng 
AB  - Most clear cell renal cell carcinomas (ccRCCs) have inactivation of the von Hippel-Lindau tumor suppressor protein (pVHL), resulting in the accumulation of hypoxia-inducible factor -subunits (HIF-) and their downstream targets. HIF-2 expression is particularly high in ccRCC and is associated with increased ccRCC growth and aggressiveness. In the canonical HIF signaling pathway, HIF-prolyl hydroxylase 3 (PHD3) suppresses HIF-2 protein by post-translational hydroxylation under sufficient oxygen av... 
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KW  - cancer; cancer biology; hypoxia; hypoxia-inducible factor (HIF); mRNA decay; ccRCC; Egl-9 family hypoxia-inducible factor 3 (EGLN3); post-transcriptional regulation; prolyl hydroxylase PHD3; renal cell carcinoma; PROLYL HYDROXYLASES; GENE-EXPRESSION; TRANSCRIPTION; HIF-1-ALPHA; PROTEIN; TRANSLATION; PROTEASOME; STABILITY; CANCER; HIF-1; 1182 Biochemistry, cell and molecular biology; 3122 Cancers 
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