TY  -  
T1  - Identification of novel regulators of STAT3 activity 
SN  -  /  
UR  - http://hdl.handle.net/10138/316193 
T3  -  
A1  - Parri, Elina; Kuusanmäki, Heikki; van Adrichem, Arjan J.; Kaustio, Meri; Wennerberg, Krister 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts as a transcription factor for its target genes, including oncogenes and cell survival regulating genes. STAT3 has been found to be persistently activated in many types of cancers, primarily through its tyrosine phosphorylation (Y705). Here, we show that constitutive STAT3 activation protects cells from cytotoxic drug responses of several drug classes. To find novel and potentially targetable STAT3 regulato... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 1182 Biochemistry, cell and molecular biology; PROTEIN-TYROSINE-PHOSPHATASE; LYMPHOPROLIFERATIVE DISORDERS; MYCOPLASMA-FERMENTANS; ACTIVATION; KINASE; CANCER; INHIBITION; TRANSCRIPTION; MUTATIONS; SRC 
N1  -   
PP  -  
ER  -