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T1  - Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour 
SN  -  /  
UR  - http://hdl.handle.net/10138/313975 
T3  -  
A1  - Garcia-Gonzalez, Judit; Brock, Alistair J.; Parker, Matthew O.; Riley, Riva J.; Joliffe, David; Sudwarts, Ari; Teh, Muy-Teck; Busch-Nentwich, Elisabeth M.; Stemple, Derek L.; Martineau, Adrian R.; Kaprio, Jaakko; Palviainen, Teemu; Kuan, Valerie; Walton, Robert T.; Brennan, Caroline H. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - To facilitate smoking genetics research we determined whether a screen of mutagenized zebrafish for nicotine preference could predict loci affecting smoking behaviour. From 30 screened F-3 sibling groups, where each was derived from an individual ethyl-nitrosurea mutagenized F-0 fish, two showed increased or decreased nicotine preference. Out of 25 inactivating mutations carried by the F-3 fish, one in the slit3 gene segregated with increased nicotine preference in heterozygous individuals. Focu... 
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KW  - CONDITIONED PLACE PREFERENCE; 5-HT1A RECEPTOR; GENE-EXPRESSION; ACOUSTIC STARTLE; DANIO-RERIO; VITAMIN-D-3 SUPPLEMENTATION; SPATIOTEMPORAL EXPRESSION; PREPULSE INHIBITION; DOPAMINE D-1; MICE LACKING; 3111 Biomedicine 
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ER  -