TY - T1 - Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes SN - / UR - http://hdl.handle.net/10138/235204 T3 - A1 - Huiskonen, Juha T. A2 - PB - Y1 - 2018 LA - eng AB - Cryogenic transmission electron microscopy (cryo-TEM) is a high-resolution biological imaging method, whereby biological samples, such as purified proteins, macromolecular complexes, viral particles, organelles and cells, are embedded in vitreous ice preserving their native structures. Due to sensitivity of biological materials to the electron beam of the microscope, only relatively low electron doses can be applied during imaging. As a result, the signal arising from the structure of interest i... VO - IS - SP - OP - KW - CRYO-EM STRUCTURE; CRYOELECTRON-MICROSCOPY; POLYMERASE COMPLEX; CHAPERONIN TRIC/CCT; DSRNA VIRUS; IN-SITU; PARTICLE; REVEALS; GENOME; RECONSTRUCTION; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -