TY  -  
T1  - Immunogenomic Landscape of Hematological Malignancies 
SN  -  /  
UR  - http://hdl.handle.net/10138/334327 
T3  -  
A1  - Dufva, Olli; Pölönen, Petri; Brück, Oscar; Keränen, Mikko A. I.; Klievink, Jay; Mehtonen, Juha; Huuhtanen, Jani; Kumar, Ashwini; Malani, Disha; Siitonen, Sanna; Kankainen, Matti; Ghimire, Bishwa; Lahtela, Jenni; Mattila, Pirkko; Vähä-Koskela, Markus; Wennerberg, Krister; Granberg, Kirsi; Leivonen, Suvi-Katri; Meriranta, Leo; Heckman, Caroline; Leppä, Sirpa; Nykter, Matti; Lohi, Olli; Heinäniemi, Merja; Mustjoki, Satu 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Understanding factors that shape the immune landscape across hematological malignancies is essential for immunotherapy development. We integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally. Infiltration of cytotoxic lymphocytes was associated with TP53 and myelodysplasia-rela... 
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KW  - CANCER-TESTIS ANTIGENS; CLASS-II EXPRESSION; COMPLEX CLASS-II; GENE-EXPRESSION; IMMUNE CELLS; TUMOR MICROENVIRONMENT; MULTIPLE-MYELOMA; INTERFERON-GAMMA; DNA METHYLATION; PD-1 BLOCKADE; 3122 Cancers; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology 
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ER  -