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T1  - Impact of first-line cancer treatment on the follicle quality in cryopreserved ovarian samples from girls and young women 
SN  -  /  
UR  - http://hdl.handle.net/10138/306993 
T3  -  
A1  - Pampanini, Valentina; Wagner, Magdalena; Asadi-Azarbaijani, Babak; Oskam, Irma C.; Sheikhi, Mona; Sjödin, Marcus O. D.; Lindberg, Johan; Hovatta, Outi; Sahlin, Lena; Bjorvang, Richelle D.; Otala, Marjut; Damdimopoulou, Pauliina; Jahnukainen, Kirsi 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - STUDY QUESTION: Does first-line chemotherapy affect the quality of ovarian pre-antral follicles and stromal tissue in a population of young patients? SUMMARY ANSWER: Exposure to first-line chemotherapy significantly impacts follicle viability, size of residual intact follicles, steroid secretion in culture and quality of the stromal compartment. WHAT IS KNOWN ALREADY: First-line chemotherapy is considered to have a low gonadotoxic potential, and as such, does not represent an indication for fert... 
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KW  - childhood cancer; chemotherapy; fertility preservation; follicle quality; DNA damage; FERTILITY PRESERVATION; INDUCED APOPTOSIS; CHILDHOOD-CANCER; DNA-DAMAGE; CHEMOTHERAPY; TISSUE; TRANSPLANTATION; OOCYTES; ACTIVATION; MECHANISMS; 3123 Gynaecology and paediatrics; 3122 Cancers 
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ER  -