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T1  - Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma 
SN  -  /  
UR  - http://hdl.handle.net/10138/224431 
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A1  - Tessier, Laurence; Cote, Olivier; Clark, Mary Ellen; Viel, Laurent; Diaz-Mendez, Andres; Anders, Simon; Bienzle, Dorothee 
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Y1  - 2017 
LA  - eng 
AB  - Background: Severe equine asthma is a naturally occurring lung inflammatory disease of mature animals characterized by neutrophilic inflammation, bronchoconstriction, mucus hypersecretion and airway remodeling. Exacerbations are triggered by inhalation of dust and microbial components. Affected animals eventually are unable of aerobic performance. In this study transcriptomic differences between asthmatic and non-asthmatic animals in the response of the bronchial epithelium to an inhaled challen... 
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KW  - Asthma; Bronchus; Differential expression analysis; High-throughput nucleotide sequencing; Horse; RECURRENT AIRWAY-OBSTRUCTION; DIFFERENTIAL EXPRESSION ANALYSIS; CELL SECRETORY PROTEIN; RNA-SEQ; GENE-EXPRESSION; SIGNALING PATHWAY; ALLERGIC-ASTHMA; IN-VITRO; GM-CSF; HORSES; 3111 Biomedicine; 1184 Genetics, developmental biology, physiology 
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