TY  -  
T1  - In Vitro Identification and In Vivo Confirmation of Inhibitors for Sweet Potato Chlorotic Stunt Virus RNA Silencing Suppressor, a Viral RNase III 
SN  -  /  
UR  - http://hdl.handle.net/10138/331648 
T3  -  
A1  - Wang, Linping; Pogue, Sylvain; Laamanen, Karoliina; Saarela, Jani; Poso, Antti; Laitinen, Tuomo; Valkonen, Jari P. T. 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Sweet potato virus disease (SPVD), caused by synergistic infection of Sweet potato chlorotic stunt virus (SPCSV) and Sweet potato feathery mottle virus (SPFMV), is responsible for substantial yield losses all over the world. However, there are currently no approved treatments for this severe disease. The crucial role played by RNase III of SPCSV (CSR3) as an RNA silencing suppressor during the viruses' synergistic interaction in sweetpotato makes it an ideal drug target for developing antiviral ... 
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IS  -  
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OP  -  
KW  - viral RNase III; RNA silencing suppressor; inhibitor identification; high-throughput screening; FRET; synergism; sweetpotato; SPCSV; EXOGENOUS APPLICATION; RIBONUCLEASE-III; MECHANISM; MOLECULES; BINDING; DSRNA; INTERFERENCE; RESISTANCE; ELIMINATION; DISCOVERY; 1182 Biochemistry, cell and molecular biology; 3121 General medicine, internal medicine and other clinical medicine 
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ER  -