TY - T1 - In situ analysis of gelatinolytic activity in human dentin SN - / UR - http://hdl.handle.net/10138/301438 T3 - A1 - Scarabello Stape, Thiago Henrique; Tjäderhane, Leo; Tezvergil-Mutluay, Arzu; Da Silva, Wagner Gomes; dos Santos Silva, Alan Roger; da Silva, Wander Jose; Marques, Marcelo Rocha A2 - PB - Y1 - 2018 LA - eng AB - Matrix metalloproteinases (MMPs) such as gelatinases are differentially expressed in human tissues. These enzymes cleave specific substrates involved in cell signaling, tissue development and remodeling and tissue breakdown. Recent evidences show that gelatinases are crucial for normal dentin development and their activity is maintained throughout the entire tooth function in the oral cavity. Due to the lack of information about the exact location and activity of gelatinases in mature human dent... VO - IS - SP - OP - KW - in situ zymography; Matrix metalloproteinases; Immunohistochemistry; Enzymes; Tooth; HUMAN CORONAL DENTIN; MATRIX METALLOPROTEINASES; IMMUNOHISTOCHEMICAL LOCALIZATION; CYSTEINE CATHEPSINS; MECHANICAL-PROPERTIES; DISTINCT ROLES; SIALOPROTEIN; PROTEIN-1; VITRO; BIOMINERALIZATION; 313 Dentistry; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -