TY  -  
T1  - In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow 
SN  -  /  
UR  - http://hdl.handle.net/10138/311133 
T3  -  
A1  - Kari, Otto K.; Ndika, Joseph; Parkkila, Petteri; Louna, Antti; Lajunen, Tatu; Puustinen, Anne; Viitala, Tapani; Alenius, Harri; Urtti, Arto 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Methodological constraints have limited our ability to study protein corona formation, slowing nanomedicine development and their successful translation into the clinic. We determined hard and soft corona structural properties along with the corresponding proteomic compositions on liposomes in a label-free workflow: surface plasmon resonance and a custom biosensor for in situ structure determination on liposomes and corona separation, and proteomics using sensitive nanoliquid chromatography tand... 
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IS  -  
SP  -  
OP  -  
KW  - 318 Medical biotechnology; PLASMON RESONANCE SENSORS; PEG CHAIN-LENGTH; BIOMOLECULAR CORONA; COMPLEMENT ACTIVATION; BIOLOGICAL IDENTITY; TIME-EVOLUTION; NANOPARTICLES; SURFACE; VIVO; ADSORPTION; PLASMON RESONANCE SENSORS; PEG CHAIN-LENGTH; BIOMOLECULAR CORONA; COMPLEMENT ACTIVATION; BIOLOGICAL IDENTITY; TIME-EVOLUTION; NANOPARTICLES; SURFACE; VIVO; ADSORPTION 
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ER  -