TY  -  
T1  - In vitro production of synthetic viral RNAs and their delivery into mammalian cells and the application of viral RNAs in the study of innate interferon responses 
SN  -  /  
UR  - http://hdl.handle.net/10138/323338 
T3  -  
A1  - Jiang, Miao; Österlund, Pamela; Poranen, Minna; Julkunen, Ilkka 
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PB  -  
Y1  - 2020 
LA  - eng 
AB  - Mammalian cells express different types of RNA molecules that can be classified as protein coding RNAs (mRNA) and non-coding RNAs (ncRNAs) the latter of which have housekeeping and regulatory functions in cells. Cellular RNAs are not recognized by cellular pattern recognition receptors (PRRs) and innate immunity is not activated. RNA viruses encode and express RNA molecules that usually differ from cell-specific RNAs and they include for instance 5'capped and 5-mono- and triphosphorylated RNAs, ... 
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KW  - 1182 Biochemistry, cell and molecular biology; 1183 Plant biology, microbiology, virology; RNA; Virus; Dendritic cells (DCs); Interferon (IFN) response; In vitro RNA production; RNA delivery; DsiRNA; Innate immunity; DOUBLE-STRANDED-RNA; SUBGENOMIC FLAVIVIRUS RNA; DENDRITIC CELLS; RIG-I; CHEMICAL-SYNTHESIS; SIRNA DELIVERY; SMALL NUCLEAR; RECOGNITION; VIRUS; POOLS 
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ER  -