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T1  - In vivo two-photon imaging of the embryonic cortex reveals spontaneous ketamine-sensitive calcium activity 
SN  -  /  
UR  - http://hdl.handle.net/10138/260569 
T3  -  
A1  - Yuryev, Mikhail; Andriichuk, Liliia; Leiwe, Marcus; Jokinen, Ville; Carabalona, Aurelie; Rivera, Claudio 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Prior to sensory experience spontaneous activity appears to play a fundamental role in the correct formation of prominent functional features of different cortical regions. The use of anaesthesia during pregnancy such as ketamine is largely considered to negatively affect neuronal development by interfering with synaptic transmission. Interestingly, the characteristics of spontaneous activity as well as the acute functional effects of maternal anaesthesia remain largely untested in the embryonic... 
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KW  - DEVELOPING MOUSE CORTEX; DEVELOPING NEOCORTEX; NEURONAL MIGRATION; NMDA RECEPTORS; CORTICAL INTERNEURONS; ELECTRICAL-ACTIVITY; WAVES; CELLS; EXPRESSION; MODULATE; 3112 Neurosciences; 3124 Neurology and psychiatry 
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ER  -