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T1  - Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation 
SN  -  /  
UR  - http://hdl.handle.net/10138/344248 
T3  -  
A1  - Byts, Nadiya; Sharma, Subodh; Malm, Tarja; Kaakinen, Mika; Korhonen, Paula; Jaakkonen, Laura; Keuters, Meike; Huuskonen, Mikko; Pietilä, Ilkka; Koistinaho, Jari; Koivunen, Peppi; Myllyharju, Johanna 
A2  -  
PB  -  
Y1  - 2022 
LA  - eng 
AB  - Hypoxia-inducible factor prolyl 4-hydroxylases (HIF-P4Hs) regulate the hypoxic induction of > 300 genes required for survival and adaptation under oxygen deprivation. Inhibition of HIF-P4H-2 has been shown to be protective in focal cerebral ischemia rodent models, while that of HIF-P4H-1 has no effects and inactivation of HIF-P4H-3 has adverse effects. A trans membrane prolyl 4-hydroxylase (P4H-TM) is highly expressed in the brain and contributes to the regulation of HIF, but the outcome of its ... 
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IS  -  
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KW  - ARTERY OCCLUSION; AGED MICE; HYPOXIA; STROKE; MECHANISMS; TRANSIENT; 3112 Neurosciences; 1182 Biochemistry, cell and molecular biology 
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