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T1  - Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior 
SN  -  /  
UR  - http://hdl.handle.net/10138/336539 
T3  -  
A1  - Tikker, Laura; Casarotto, Plinio; Singh, Parul; Biojone, Caroline; Piepponen, T. Petteri; Estartus, Nuri; Seelbach, Anna; Sridharan, Ravindran; Laukkanen, Liina; Castren, Eero; Partanen, Juha 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Serotonergic neurons in the dorsal raphe (DR) nucleus are associated with several psychiatric disorders including depression and anxiety disorders, which often have a neurodevelopmental component. During embryonic development, GATA transcription factors GATA2 and GATA3 operate as serotonergic neuron fate selectors and regulate the differentiation of serotonergic neuron subtypes of DR. Here, we analyzed the requirement of GATA cofactor ZFPM1 in the development of serotonergic neurons using Zfpm1 ... 
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KW  - anxiety; differentiation; dorsal raphe; embryo; serotonergic neuron; transcription factor; ELEVATED PLUS-MAZE; CHROMATIN OCCUPANCY; VENTRAL HIPPOCAMPUS; MICE LACKING; FEAR; AMYGDALA; SYSTEM; MEMORY; FRIEND; FOG-2; 3112 Neurosciences; 3124 Neurology and psychiatry 
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