TY - T1 - Increased Oxidative Stress in the Proximal Stomach of Patients with Barrett's Esophagus and Adenocarcinoma of the Esophagus and Esophagogastric Junction SN - / UR - http://hdl.handle.net/10138/169572 T3 - A1 - Kauppi, Juha; Räsänen, Jari; Sihvo, Eero; Nieminen, Urpo; Arkkila, Perttu; Ahotupa, Markku; Salo, Jarmo A2 - PB - Y1 - 2016 LA - eng AB - OBJECTIVES: Oxidative stress (OS) is an essential element in the pathogenesis of Barrett's esophagus (BE) and its transformation to adenocarcinoma (EAC). The state of OS in the proximal stomach of patients with BE and EAC is unknown. Isoprostanes are a specific marker of OS not previously used to determine OS from BE/EAC tissue samples. PATIENTS AND METHODS: OS was measured in 42 patients with BE (n = 9), EAC (n = 9), or both (n = 24) and 15 control patients. A STAT-8-Isoprostane EIA Kit served ... VO - IS - SP - OP - KW - HELICOBACTER-PYLORI INFECTION; GASTROESOPHAGEAL-REFLUX; FREE-RADICALS; GASTRIC CARDIA; DNA-ADDUCTS; CANCER; GLUTATHIONE; CARCINOGENESIS; INFLAMMATION; EXPRESSION; 3122 Cancers; 3126 Surgery, anesthesiology, intensive care, radiology; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -