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T1  - Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms 
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UR  - http://hdl.handle.net/10138/322335 
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A1  - Keindl, Magdalena; Fedotkina, Olena; du Plessis, Elsa; Jain, Ruchi; Bergum, Brith; Mygind Jensen, Troels; Laustrup Moller, Cathrine; Falhammar, Henrik; Nystrom, Thomas; Catrina, Sergiu-Bogdan; Jorneskog, Gun; Groop, Leif; Eliasson, Mats; Eliasson, Bjorn; Brismar, Kerstin; Nilsson, Peter M.; Berg, Tore Julsrud; Appel, Silke; Lyssenko, Valeriya 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic beta cells. Further, patients with T1D have 3-4-fold increased risk of developing micro- and macrovascular complications. However, the contribution of immune-related factors contributing to these diabetes complications are poorly understood. Individuals with long-term T1D who do not progress to vascular complications offer a great potential to evaluate end-organ protection... 
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KW  - cardiovascular disease; Cluster of Differentiation 25 (CD25); diabetes complications; nephropathy; regulatory T cells; retinopathy; sIL-2R; REGULATORY T-CELLS; DISEASE; RETINOPATHY; INDIVIDUALS; AUTOIMMUNE; RISK; SUPPRESSION; MECHANISMS; CYTOKINES; MELLITUS; 1184 Genetics, developmental biology, physiology; 3121 General medicine, internal medicine and other clinical medicine 
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