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T1  - Increased Serum Levels of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Subjects With Parkinson’s Disease 
SN  -  /  
UR  - http://hdl.handle.net/10138/308489 
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A1  - Galli, Emilia; Planken, Anu; Kadastik-Eerme, Liis; Saarma, Mart; Taba, Pille; Lindholm, Päivi 
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PB  -  
Y1  - 2019 
LA  - eng 
AB  - Background: Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) promote the survival of midbrain dopamine neurons in animal models of Parkinson's disease (PD). However, little is known about endogenous concentrations of MANF and CDNF in human PD patients, and their relation to PD pathogenesis. Our main objective was to study whether circulating concentrations of MANF and CDNF differ between PD patients and controls, and if they correlate wi... 
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OP  -  
KW  - 1182 Biochemistry, cell and molecular biology; Parkinson's disease; MANF; CDNF; blood; ELISA; MIDBRAIN DOPAMINE NEURONS; CDNF PROTECTS; RAT MODEL; PROGRESSION; DEPRESSION; ACCURACY; SCALE; UPDRS; ONSET 
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ER  -