TY  -  
T1  - Increased alpha-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer 
SN  -  /  
UR  - http://hdl.handle.net/10138/237101 
T3  -  
A1  - Kovac, Bianca; Makela, Tomi P.; Vallenius, Tea 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - The controlled formation and stabilization of E-cadherin-based adhesions is vital for epithelial integrity. This requires co-operation between the E-cadherin-based adhesions and the associated actin cytoskeleton. In cancer, this co-operation often fails, predisposing cells to migration through molecular mechanisms that have only been partially characterized. Here, we demonstrate that the actin filament cross-linker alpha-actinin-1 is frequently increased in human breast cancer. In mammary epithe... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-CELL JUNCTIONS; ALPHA-ACTININ; GENE-EXPRESSION; INDEPENDENT MANNER; ADHERENS JUNCTIONS; OVARIAN-CANCER; TGF-BETA; INVASION; 3111 Biomedicine; 3122 Cancers 
N1  -   
PP  -  
ER  -