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T1  - Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients 
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UR  - http://hdl.handle.net/10138/324906 
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A1  - Airaksinen, Laura; Laurikka, Pilvi; Huhtala, Heini; Kurppa, Kalle; Salmi, Teea; Saavalainen, Päivi; Kaukinen, Katri; Lindfors, Katri 
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PB  -  
Y1  - 2020 
LA  - eng 
AB  - The clinical phenotype of celiac disease varies considerably among patients and the dosage of HLA-DQ2.5 alleles has been suggested to be a contributing factor. We investigated whether HLA-DQ2.5 allele dosage is associated with distinct clinical parameters at the time of diagnosis and with patients' response to a gluten-free diet. The final cohort included 605 carefully phenotyped non-related Finnish celiac disease patients grouped as having 0, 1 or 2 copies of HLA-DQ2.5. Clinical data at the tim... 
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KW  - celiac disease; HLA-DQ2; 5; dose effect; clinical presentation; gluten-free diet; DUODENAL MICROBIOTA COMPOSITION; GLUTEN-FREE DIET; GASTROINTESTINAL SYMPTOMS; IGA; SUSCEPTIBILITY; ANTIBODIES; GENES; 3121 General medicine, internal medicine and other clinical medicine; 3111 Biomedicine; 3143 Nutrition 
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