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T1  - Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes 
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UR  - http://hdl.handle.net/10138/229281 
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A1  - Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Soderholm, Sandra; Gaelings, Lana; Ohman, Tiina; Tynell, Janne; Kyttanen, Suvi; Barboric, Matjaz; Nyman, Tuula A.; Matikainen, Sampsa; Julkunen, Ilkka; Butcher, Sarah J.; Egly, Jean-Marc; Kainov, Denis E. 
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Y1  - 2016 
LA  - eng 
AB  - Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and sec... 
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KW  - 3111 Biomedicine; Regulation of gene expression; Influenza A virus; Innate immunity; Antiviral responses; Viral counter-responses; DOUBLE-STRANDED-RNA; A VIRUS; INDUCIBLE GTPASES; VIRAL-INFECTIONS; EPITHELIAL-CELLS; STRUCTURAL BASIS; INNATE IMMUNITY; B VIRUSES; INTERFERON; EXPRESSION; 1183 Plant biology, microbiology, virology; 1182 Biochemistry, cell and molecular biology 
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