TY - T1 - Inhibition of β2 Integrin–mediated Leukocyte Cell Adhesion SN - / UR - http://hdl.handle.net/1975/550 T3 - A1 - Koivunen, Erkki; Ranta, Tanja-Maria; Annila, Arto; Taube, Seija; van Willigen, Gijsbert; Ihanus, Eveliina; Gahmberg, Carl G. A2 - PB - Rockefeller University Press Y1 - 2001 LA - en AB - Many integrins mediate cell attachment to the extracellular matrix by recognizing short tripeptide sequences such as arginine–glycine–aspartic acid and leucine–aspartate–valine. Using phage display, we have now found that the leukocyte-specific b2 integrins bind sequences containing a leucine–leucine–glycine (LLG) tripeptide motif. An LLG motif is present on intercellular adhesion molecule (ICAM)-1, the major b2 integrin ligand, but also on several matrix proteins, including von Willebrand facto... VO - IS - SP - OP - KW - cell adhesion; extracellular matrix; leukocyte; phage display; peptides N1 - PP - ER -