TY  -  
T1  - Inhibition of Nonessential Bacterial Targets : Discovery of a Novel Serine O-Acetyltransferase Inhibitor 
SN  -  /  
UR  - http://hdl.handle.net/10138/326416 
T3  -  
A1  - Pinto de Magalhães, Joana; Franko, Nina; Raboni, Samanta; Annunziato, Giannamaria; Tammela, Päivi; Bruno, Agostino; Bettati, Stefano; Mozzarelli, Andrea; Pieroni, Marco; Cambanini, Barbara; Costantino, Gabriele 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - In Upsilon-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable during persistence and become dispensable during growth or acute infection. The biosynthetic machinery required to convert inorganic sulfur into cysteine is absent in mammals; therefore, it is a suitable drug target. We searched for inhibitors of Salmonella serine acetyltransferase (SAT), the enzyme that catalyzes the rate-limiting step of L-cysteine biosynthesis. The virtual screening of three ChemDiv... 
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IS  -  
SP  -  
OP  -  
KW  - Adjuvant therapies; Antimicrobial resistance; CARBOXYLIC-ACIDS; COMPLEX; Cysteine biosynthesis; ESCHERICHIA-COLI; KINETIC MECHANISM; L-CYSTEINE; Nonessential targets; PURIFICATION; Serine acetyltransferase; 317 Pharmacy; 116 Chemical sciences; 11832 Microbiology and virology 
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ER  -