TY  -  
T1  - Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells 
SN  -  /  
UR  - http://hdl.handle.net/10138/321575 
T3  -  
A1  - Barkovskaya, Anna; Seip, Kotryna; Prasmickaite, Lina; Mills, Ian G; Moestue, Siver A; Itkonen, Harri M. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of estrogen receptor (ERa), a transcription factor expressed in over 50% of breast cancers. ERa-positive breast cancers are successfully treated with tamoxifen; however, a significant number of patients develop tamoxifen-resistant disease. We show that in vitro development of tamoxifenresistanc... 
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IS  -  
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OP  -  
KW  - DATABASE; DRIVEN; GLCNACYLATION; MECHANISMS; METABOLISM; MYC; N-ACETYLGLUCOSAMINE; OGT ACTIVITY; PATHWAY; 3111 Biomedicine 
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ER  -