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T1  - Insulin exposure mitigates the increase of arterial stiffness in patients with type 2 diabetes and albuminuria: an exploratory analysis 
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UR  - http://hdl.handle.net/10138/306732 
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A1  - Gordin, Daniel; Saraheimo, Markku; Tuomikangas, Jaana; Soro-Paavonen, Aino; Forsblom, Carol; Paavonen, Karri; Steckel-Hamann, Birgit; Harjutsalo, Valma; Nicolaou, Loizos; Pavo, Imre; Koivisto, Veikko; Groop, Per-Henrik 
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Y1  - 2019 
LA  - eng 
AB  - Aims Insulin possesses both vasodilatory and sympathomimetic activities. The aim was to examine the relationship between changes in insulin exposure and arterial stiffness in type 2 diabetes (T2D). Methods Patients with T2D with (n = 22) or without (n = 24) albuminuria, and non-diabetic controls (n = 25) were randomized to a crossover study having a breakfast with or without pre-meal rapid-acting insulin. Pulse wave velocity (PWV) was measured at 30 min before and at 60-min intervals up to 240 m... 
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KW  - 3121 General medicine, internal medicine and other clinical medicine; Type 2 Diabetes; Pulse wave velocity; Arterial stiffness; Insulin resistance; Albuminuria; Diabetic nephropathy; Diabetic kidney disease; VASODILATION 
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