TY  -  
T1  - Interaction between IDH1 WT and calmodulin and its implications for glioblastoma cell growth and migration 
SN  -  /  
UR  - http://hdl.handle.net/10138/328370 
T3  -  
A1  - Kang, Sunmi; Kwon, Hyuk Nam; Kang, Soeun; Park, Sunghyouk 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Isocitrate dehydrogenase (IDH) mutations are found in low-grade gliomas, and the product of the IDH mutant (MT), 2-hydroxyglutarate (2-HG), is the first known oncometabolite. However, the roles of the IDH wild type (WT) in high-grade glioblastoma, which rarely has the IDH mutation, are still unknown. To investigate possible pathways related to IDH WT in gliomas, we carried out bioinformatics analysis, and found that IDH1 has several putative calmodulin (CaM) binding sites. Pull-down and quantita... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Isocitrate dehydrogenase (IDH); Glioblastoma multiforme (GBM); Calmodulin (CaM); Interaction; Protein structure; Binding sites; ANTIPSYCHOTIC-DRUG TRIFLUOPERAZINE; K-RAS; BINDING; MUTATIONS; INVASION; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -