TY  -  
T1  - Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions 
SN  -  /  
UR  - http://hdl.handle.net/10138/299408 
T3  -  
A1  - Semjonov, Kristian; Salm, Maia; Lipiäinen, Tiina; Kogermann, Karin; Lust, Andres; Laidmäe, Ivo; Antikainen, Osmo; Strachan, Clare J.; Ehlers, Henrik; Yliruusi, Jouko; Heinämäki, Jyrki 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Solid dispersions (SDs) hold a proven potential in formulating poorly water-soluble drugs. The present paper investigates the interfacial phenomena associated with the bulk powder flow, water sorption, wetting and dissolution of the SDs prepared by a modified melt and quench-cooling (QC) method. Poorly water-soluble indomethacin (IND) was QC molten with solubilizing graft copolymer (Soluplus (R)) or polyol sugar alcohol (xylitol, XYL). The interfacial interactions of SDs with air/water were foun... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - particle properties; bulk powder behavior; dissolution; solid dispersion; polymer; HOT-MELT EXTRUSION; WATER-SOLUBLE DRUG; AMORPHOUS INDOMETHACIN; DISSOLUTION RATE; PHYSICAL STABILITY; MIXTURES; SIZE; BIOAVAILABILITY; FLOWABILITY; FORMULATION; 317 Pharmacy 
N1  -   
PP  -  
ER  -