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T1  - Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells 
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UR  - http://hdl.handle.net/10138/229856 
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A1  - Lehti, Timo A.; Pajunen, Maria I.; Skog, Maria S.; Finne, Jukka 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Eukaryotic organisms are continuously exposed to bacteriophages, which are efficient gene transfer agents in bacteria. However, bacteriophages are considered not to pass the eukaryotic cell membrane and enter nonphagocytic cells. Here we report the binding and penetration of Escherichia coli PK1A2 bacteriophage into live eukaryotic neuroblastoma cells in vitro. The phage interacts with cell surface polysialic acid, which shares structural similarity with the bacterial phage receptor. Using fluor... 
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KW  - HORIZONTAL GENE-TRANSFER; HUMAN GUT VIROME; ADHESION MOLECULE; PHAGE DISPLAY; TERMINAL PROTEINS; IN-VIVO; BACTERIAL; MIMICRY; BRAIN; ENDOSIALIDASE; 1182 Biochemistry, cell and molecular biology 
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ER  -