TY  -  
T1  - Intracellular delivery of budesonide and polydopamine co-loaded in endosomolytic poly(butyl methacrylate-co-methacrylic acid) grafted acetalated dextran for macrophage phenotype switch from M1 to M2 
SN  -  /  
UR  - http://hdl.handle.net/10138/333012 
T3  -  
A1  - Wang, Shiqi; Wannasarit, Saowanee; Figueiredo, Patricia; Molinaro, Giuseppina; Ding, Yaping; Correia, Alexandra; Casettari, Luca; Wiwattanapatapee, Ruedeekorn; Hirvonen, Jouni; Liu, Dongfei; Li, Wei; Santos, Hélder A. 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - In this study, a rationally designed nanocomposite (BUDPDA@MAP) composed of polydopamine (PDA) nanoparticle and anti‐inflammatory drug budesonide (BUD) encapsulated in a pH‐responsive endosomolytic polymer (poly(butyl methacrylate‐co‐methacrylic acid) grafted acetalated dextran, denoted by MAP), is proposed. The uniform nanocomposite is prepared using a microfluidic device. At low endosomal pH (5.5), MAP destabilizes the endosomal membranes for the cytoplasmic delivery of PDA, and releases BUD s... 
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KW  - ANTIGEN; ENHANCEMENT; INFLAMMATION; NANOPARTICLES; PEPTIDES; POLYMERS; drug delivery; endosomal escape; macrophage phenotypes; microfluidics; polydopamine; 317 Pharmacy; 221 Nano-technology; 318 Medical biotechnology 
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