TY  -  
T1  - Intracellular distribution of drugs (Literature review) : Subcellular fractionation protocol to isolate plasma membrane and cytoplasm of MDCKII cells (Experimental work) 
SN  -  /  
UR  - URN:NBN:fi-fe201801151245; http://hdl.handle.net/10138/42412 
T3  -  
A1  - Huusko, Karoliina 
A2  -  
PB  - Helsingfors universitet 
Y1  - 2013 
LA  - eng 
AB  - Intracellular drug sequestration is useful to understand when designing new drugs with intracellular targets. The knowledge of the intracellular distribution can also help to understand the side effects and pharmacokinetics of a drug, as well as the lack of response in e.g. some multidrug resistant cancer cells. Intracellular concentrations are also important to know when predicting the role of active transport in the overall transport process when binding site of the transporter is intracellula... 
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IS  -  
SP  -  
OP  -  
KW  - MDR1; MDCKII; intracellular distribution; drug sequestration; subcellular fractionation; solunsisäinen jakautuminen; lääkeaineiden jakautuminen; solunosien fraktiointi; Biofarmaci; Biopharmacy; Biofarmasia 
N1  -   
PP  -  
ER  -